WebEnter the email address you signed up with and we'll email you a reset link. Webnatural product thailandamide lactone† Himangshu Sharma,a Joyanta Mondal,a Ananyo K. Ghosh,b Ritesh Ranjan Pal b and Rajib Kumar Goswami *a Stereoselective total synthesis …

The Polyene Natural Product Thailandamide A Inhibits …

Web5 Jul 2024 · Thailandamide A is effective against Gram-positives, but it is less effective against Gram-negative bacteria (except Neisseria gonorrheae). It is interesting to note … Web16 Mar 2024 · Analysis of B. thailandensis transposon mutants for thailandamide production revealed that thailandamide was bioactive against F. johnsoniae, but also suggested that additional B. thailandensis -produced antibiotics were involved in the inhibition of F. johnsoniae. cube stereo hybrid 750 sl

Discovery of scmR as a global …' href='https://www.pnas.org/doi/pdf/10.1073/pnas.1619529114' >WebIt is a hybrid polyketide/nonribosomal peptide and a potent inhibitor of some histone deacetylases (HDACs). Finally, the lasso peptide capistruin was identified by heterologous ex- pression in Escherichia coli and by subjecting B. thailandensis to heat stress (18). It is not produced under normal growth condi- tions. Frontiers Engineering of Burkholderia thailandensis strain E264 ... Web17 Nov 2024 · Heterologous expression is an indispensable approach to exploiting natural products from phylogenetically diverse microbial communities. In this study, we constructed a heterologous expression system based on strain Burkholderia thailandensis E264 by deleting efflux pump genes and screening constitutive strong promoters. The biosynthetic … https://www.frontiersin.org/articles/10.3389/fmicb.2024.1073243/full Pyochelin - an overview ScienceDirect Topics WebOr consider B. thailandensis E264, which produces inhibitors of the ribosome (bactobolin), RNAP (capistruin), pyrimidine biosynthesis (HMNQ/HQNO), fatty acid synthesis (thailandamide), various HDACs (burkholdacs), and energy production pathways (also HMNQ/HQNO). 55 These impressive metabolic outputs hint at a superb evolutionary … https://www.sciencedirect.com/topics/chemistry/pyochelin Total Synthesis of Antibacterial Polyketide Natural Product ... Web26 Oct 2024 · The antibacterial activity of thailandamide lactone was also evaluated. Discover the world's research. 20+ million members; 135+ million publication pages; 2.3+ … https://www.researchgate.net/publication/364734438_Total_Synthesis_of_Antibacterial_Polyketide_Natural_Product_Thailandamide_Lactone Total synthesis of the antibacterial polyketide natural product ... Web21 Oct 2024 · Stereoselective total synthesis of the structurally intriguing polyketide natural product thailandamide lactone was accomplished, and done so using a convergent … https://pubmed.ncbi.nlm.nih.gov/36507156/ Polyenes. (29) thailandamide A. (30) thailandene A. (31) … WebThis species produces the polyene polyketide thailandamide A (29) (Figure 3) inhibiting notably bacteria such as Bacillus subtilis, S. aureus, and Neisseria gonorrhoeae [42]. … https://www.researchgate.net/figure/Polyenes-29-thailandamide-A-30-thailandene-A-31-thailandene-B-32-thailandene_fig1_368472751 BGC0000186 - mibig.secondarymetabolites.org WebBGC0000186: thailandamide biosynthetic gene cluster from Burkholderia thailandensis E264 View antiSMASH-generated output Download Cluster GenBank file Download region SVG … https://mibig.secondarymetabolites.org/repository/BGC0000186/index.html Exploiting the mosaic structure of trans-acyltransferase polyketide … Web27 Jan 2008 · Thailandamide B was a highly unstable geometrical isomer that partially isomerized to thailandamide A and decomposed during NMR measurements. https://www.nature.com/articles/nbt1379 Thailandamide, a Fatty Acid Synthesis Antibiotic That Is … Web18 Jun 2024 · Thailandamide, a Fatty Acid Synthesis Antibiotic That Is Coexpressed with a Resistant Target Gene DOI: Authors: Christopher E. Wozniak Zhenjian Lin Eric Schmidt … https://www.researchgate.net/publication/325825910_Thailandamide_a_Fatty_Acid_Synthesis_Antibiotic_That_Is_Coexpressed_with_a_Resistant_Target_Gene Katelyn Billings - Director, Discovery Chemistry - Relay … WebDesigned and implemented scalable, convergent routes toward key fragments of the polyketide natural products Thailandamide A and Nosperin. Adapted synthetic routes and identified new ... https://www.linkedin.com/in/katelyn-billings-73826ba7 Induced biosynthesis of cryptic polyketide metabolites in a ... Web13 Oct 2010 · A novel polyketide metabolite, thailandamide lactone (2), which cannot be detected in the wild type, was isolated from the mutant broth, and its structure was … https://pubmed.ncbi.nlm.nih.gov/20853892/ Do Global Regulators Hold the Key to Production of Bacterial … WebThailandamide tha ThaA (Orphan LuxR) Acetyl-CoA Carboxylase Burkholdacs bhc BhcM (AraC) Histone Deacetylase Pyoverdine pvc BTH_II2035 (LTTR)? Unknown Siderophore Ornibactin orb OrbS (ECF) Siderophore Thailanstatin tst TstA (Orphan LuxR) Spliceosome Figure 1. Chemical structures of selected secondary metabolites. https://mdpi-res.com/d_attachment/antibiotics/antibiotics-08-00160/article_deploy/antibiotics-08-00160.pdf?version=1569224365 Thailandamide, a Fatty Acid Synthesis Antibiotic That Is … WebMutants of Salmonella resistant to thailandamide had mutations in the accA gene for acetyl coenzyme A (acetyl-CoA) carboxylase, which is one of the first enzymes in the fatty acid … https://journals.asm.org/doi/epub/10.1128/AAC.00463-18 Genome-guided discovery of diverse natural products from Web9 Nov 2013 · The authors predicted two slightly different versions of a complicated long chain polyene product using two distinctive prediction methods, which led to the discovery of thailandamide A (11), its congener thailandemide B (12), and thailandemide lactone (13) (Fig. 4) [22, 23, 41]. Those compounds are elusive because they are produced in minute ... https://link.springer.com/article/10.1007/s10295-013-1376-1 Total synthesis of the antibacterial polyketide natural … Web21 Oct 2024 · Structurally, thailandamide lactone 2 is a linear polyene polyketide where a tetraene conjugated with a γ-butyrolactone is fused with a conjugated triene through an … https://pubs.rsc.org/en/content/articlelanding/2024/sc/d2sc04727f#! Kelly Hughes - Bioscience - The University of Utah Web17 Jul 2024 · Aizawa, and K.T. Hughes. The role of the FliK molecular ruler in hook-length control in Salmonella enterica. Molec. Microbiol. (2010), 75: 1272-1284. Wozniak, C.E., F.F.V. Chevance, and Hughes KT. Multiple promoters contribute to swarming and the coordination of transcription with flagellar assembly in Salmonella. https://bioscience.utah.edu/faculty/hughes-kelly/ The Polyene Natural Product Thailandamide A Inhibits … Webwith a certain volume of 10 mM thailandamide solution in DMSO at 37°C, giving a final concentration of 100 µM. A 5 mL overnight LB culture of B. subtilis was dilut3610 ed … https://pubs.acs.org/doi/suppl/10.1021/acs.biochem.8b00678/suppl_file/bi8b00678_si_001.pdf Structural and Functional Trends in Dehydrating Bimodules from … Webgicin, and thailandamide assembly lines (type A: BaeK/BaeL, Figure 1. Structural and Functional Schematics of Type A and B Dehydrating Bimodules (A) Type A dehydrating bimodules are typically split into polypeptides containing KS + KR A + ACP + KS 0 and DH + ACP. The KS that follows the first module https://www.cell.com/structure/pdf/S0969-2126(17)30145-4.pdf

Web20 Sep 2010 · Genetic manipulation of the LuxR-type quorum sensing regulator system in Burkholderia thailandensis caused a significant change in the metabolic profile: it led to … WebIdentified secondary metabolite regions using strictness 'relaxed' NZ_KV440970.1 (Bacillus halotolerans) . Region Type From To Most similar known cluster Similarity east coast radio internship