WebMar 1, 2024 · This randomized, double-blind controlled trial of everolimus in individuals with germline phosphatase and tensin homolog mutations (PTEN) was designed to evaluate … WebKey words: carcinogenesis, PTEN mutation, MMAC-1 mutation, TEP-1 mutation, cancer genetics. Słowa kluczowe: kancerogeneza, mutacje genu PTEN, mutacje MMAC-1, mutacje TEP-1, ... everolimus in a patient with metastatic castrate-resistant prostate cancer harboring a PTEN inactivating mutation. Case Rep Oncol 2024; 13: 456-4461.
Response and Acquired Resistance to Everolimus in Anaplastic …
WebUsing WES, we found uLMS to harbor mutations in well-recognized cancer genes, including TP53 (altered in 60%), RB1 (altered in 55%), and PTEN (altered in 31%). … WebJan 15, 2024 · PTEN Expression, Not Mutation Status in TSC1, TSC2, ... Across 100 patients treated with first-line everolimus, PTEN expression was retained in 50 (50%); … esztergom szent istván fürdő
PTEN status is a crucial determinant of the functional outcome of ...
WebMolecular diagnosis of Inherited Retinal Dystrophies (IRD) has long been challenging due to the extensive clinical and genetic heterogeneity present in this group of disorders. Here, we describe the clinical application of an integrated next-generation sequencing approach to determine the underlying genetic defects in a Spanish family with a provisional clinical … WebThis randomized, double-blind controlled trial of everolimus in individuals with germline phosphatase and tensin homolog mutations (PTEN) was designed to... DOAJ is a … WebPTEN mutation in NSCLC may be sensitizing to analogs of rapamycin such as everolimus or temsirolimus, but more investigation is needed. We report the case of a patient with metastatic NSCLC harboring a PTEN mutation as well as high tumor mutational burden and PD-L1 positivity with a durable response to temsirolimus, but refractory to a ... esztergom szent adalbert