Protein ndrg1 isoform 2
As reviewed by Kovacevic et al., NDRG1 is a potent, iron-regulated growth and metastasis suppressor that was found to be negatively correlated with cancer progression in a number of tumors, including prostate, pancreatic, breast, and colon cancers. NDRG1 has marked anti-oncogenic activity, being associated with decreased cell proliferation, migration, invasion, and angiogenesis. The molecular functions of NDRG1 affect numerous signaling pathways that regul… Webb4 jan. 2024 · NDRG1 regulates the expression of the membrane protein KAI1 (CD82), which interacts with adjacent cells via the membrane protein gp-Fγ to inhibit metastasis 57.
Protein ndrg1 isoform 2
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WebbFurther studies identified two additional NDRG1 protein targets. The dominant-negative p63 isoform, ΔNp63, which has been found to inhibit p21 transcription, was downregulated by NDRG1. On the other hand, a truncated 50 kDa MDM2 isoform (p50(MDM2)), which may protect p21 from proteasomal degradation, was upregulated by NDRG1. The ... Webb1 sep. 2024 · Fig. 2. NDRG1 protein structure. The NDRG1 protein is composed of 394 amino acids with its distinct three tandem repeats (GTRSRSHTSE; ... This latter study has also shown that all the NDRG1 isoform products that are generated by the proteasome and lysosome are at least partially phosphorylated.
Webb1 sep. 2024 · The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), is a stress response protein that is involved in the inhibition of multiple oncogenic signaling pathways. Initial studies have linked NDRG1 and the … Webb767952383 - Protein Result 1. protein NDRG1 isoform X2 [Homo sapiens] 205 aa protein Record removed. This record was removed as a result of standard genome annotation …
WebbA protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences. … WebbDownload scientific diagram High molecular mass 46 kDa NDRG1 isoform identified in DU145 cells is not due to phosphorylation Analysis of (A) NDRG1 dephosphorylation assay using phosphatases and ...
WebbNDRG1 INFORMATION. Proteini. Full gene name according to HGNC. N-myc downstream regulated 1. Gene namei. Official gene symbol, which is typically a short form of the gene …
WebbThe Tissue section contains information regarding the expression profile of human gene both on the mRNA and protein level. The protein expression data from 44 normal tissue … other words for dry iceWebbNDRG1 - Function 1 GENE 3 ISO 282 REF Gold Only Extend overview NDRG1 → Protein NDRG1 Protein also known as : Reducing agents and tunicamycin-responsive protein (RTP) . Gene name : NDRG1 Family name : NDRG Entry whose protein (s) existence is based on evidence at protein level. Show evidences other words for dwindlingWebbNDRG1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas … rockledge permit searchWebbFT CHAIN 2-394 Protein NDRG1. Molecular weight (Da) 42704.25 Theoretical pI . 5.49 NDRG1 Protein Interaction . Recombinant NDRG1 Protein Feature . NDRG1 Protein, … rockledge pediatrics in brevardWebbProtein: protein NDRG1: Source: NCBI Accessed: 31 August, 2024: Ontology: What does this gene/protein do? Show (21) Contents Gene ... (p-NDRG1) at Ser330 and Thr346. The … other words for each otherWebbNDRG1 Imported Organism names Organism Homo sapiens (Human) Imported Taxonomic identifier 9606 NCBI Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > … rockledge pd non emergency numberWebbAbout NDRG1 Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,237,175-133,297,252 (from NCBI) This gene has 61 transcripts (splice variants), … rockledge personal injury attorney