WebNK cells were then co-cultured with the HCC cell line in vitro to detect effects on HCC cell progression after Fidarestat administration. The glycolysis activity of the NK cells was evaluated by extracellular acidification rate, while aldo-keto reductase family 1 member B10 (AKR1B10) expression was detected by western blot analysis. WebMar 25, 2024 · PLZF (encoded by Zbtb16) is a BTB-zinc finger transcription factor expressed by innate-like T cells, including NKT cells but not by conventional T cells or NK cells (20, 21).PLZF regulates early developmental and functional differentiation of NKT cells. Zbtb16 mutation or deletion leads to abrogation of expansion and effector-memory …
Frontiers Glycolysis and Oxidative Phosphorylation Play Critical ...
WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources WebFeb 5, 2024 · Glycolysis regulates many important functions of neutrophils, activated NK cell and DC cells, therefore, people expect to control the tumor immunity by regulating the glycolytic changes of immune cells, which is also an important direction for future research . However, this is far from actual clinical application and need further study. halaxy book appointment
Decreased glycolysis induced dysfunction of NK cells in …
WebTreg cells can produce an immunosuppressive environment by secreting transforming growth factor beta and IL-10, attenuating the anti-tumor effects produced by CD4+ T cells, CD8+ T cells and NK cells. 17–19 Tumor-associated macrophages can act on tumor cells through chemokines, growth factors, and angiogenic factors, thereby promoting tumor ... WebJun 1, 2024 · Because glycolysis produces both ATP and substrates for biosynthetic pathways (e.g., nucleotide production) (Lane and Fan, 2015), we investigated the dependence of NK cell functional responses on aerobic glycolysis using a NK cell-specific genetic ablation of lactate dehydrogenase A (LDHA), as well as in vivo models of viral … WebFidarestat promotes NK cell function to inhibit HCC cell proliferation, invasion, and metastasis in vitro. To explore the role of Fidarestat in the killing ability of NK cells, NK … bullzeye oilfield services llc