Elf4 function
WebPlays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 … WebDec 19, 2016 · It was noted that circadian components function in plant adaptation to diurnal temperature cycles and freezing tolerance. Our genome-wide transcriptome analysis revealed that evening-phased COR27 and COR28 mainly repress the transcription of clock-associated evening genes PRR5, ELF4 and cold-responsive genes. Chromatin …
Elf4 function
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WebWe identified ELF4 p.T187N as resulting in NK cell-focused dysregulation, with impaired ELF4 function resulting from decreased binding. Variants in different regions likely yield … WebAug 4, 2024 · After identifying the ELF4 variant, Lucas’s lab then studied its effects in cultured cells from patients, as well as in mice using CRISPR gene-editing to introduce patient-derived ELF4 mutations. They confirmed that the variant disrupted ELF4 function, and resulted in elevated inflammatory responses of a variety of immune cell types. ...
WebDec 20, 2024 · An ELF4 hypomorphic variant results in NK cell deficiency. that E74, like ETS transcription factor 4 (ELF4), a type I interferon activator, can help protect the host from Plasmodium yoelii infection. Transcription factor ELF4 promotes development and function of memory CD8 (+) T cells in Listeria monocytogenes infection. WebDec 1, 2013 · ELF4, a member of the ETS transcription factors, can function as an oncogene in murine cancer models and is overexpressed in various human cancers …
WebSep 5, 2002 · ELF4 promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. elf4 mutants show attenuated expression of CIRCADIAN CLOCK ASSOCIATED 1 (CCA1), a gene that is thought to function as a central oscillator component. In addition, elf4 plants transiently show output rhythms with highly variable … WebELF4 INFORMATION; Protein i. E74 like ETS transcription factor 4: Gene name i. ELF4 (ELFR, MEF) ... (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a ...
WebJun 1, 2024 · ELF4 carries out these functions as a transcriptional activator or through interactions with its partner proteins. Mutations in ELF4 cause aberrant interactions and …
WebMar 9, 2024 · Loss of Function of ELF4 Leads to Impaired Viral Clearance. We previously showed ELF4 is critical for host innate immune defense against viral infection . And also … cumberland me city hallWebMoriquendi is a fictional race of elves in J. R. R. Tolkien's legendarium. Drow, or dark elves, is a fictional subrace of elves in Dungeons & Dragons and novels by R. A. Salvatore … cumberland me assessor databaseWebDec 24, 2024 · E74 like ETS transcription factor 4 provided by HGNC. Primary source. RefSeq status. Organism. Lineage. Also known as. Summary. The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development … eastsport bagsWebFeb 23, 2024 · We discovered loss-of-function variants in the X-linked ETS transcription factor gene ELF4 in multiple unrelated male patients with early onset mucosal autoinflammation and inflammatory bowel ... cumberland medical center imagingWebNov 4, 2024 · An example of this mechanism is demonstrated by ELF4, which exerts its antiviral function through feeding-forward to produce more interferon . Another example of such a positive feedback loop is seen in the ISG IRF1, which takes a two-pronged approach to viral inhibition by triggering the production of interferon, as well as regulating its own ... cumberland medical center billingWebJan 6, 2024 · While the activating function of ELF4 has been mechanistically explained and proved through deletion studies of its transactivation domain, the mechanism of how ELF4 exerts its repressing capability has not been clearly elucidated. It is possible that ELF4 can recruit certain co-repressors to the promoter region of its target genes. cumberland medical associates fayettevilleWeb摘要： It was noted that circadian components function in plant adaptation to diurnal temperature cycles and freezing tolerance. Our genome-wide tran-scriptome analysis revealed that evening-phased COR27 and COR28 mainly repress the transcription of clock-associated evening genes PRR5, ELF4 and cold-respon-sive genes. east springfield dialysis springfield ma