2024 Dual specificity protein kinase clk2

Dual specificity protein kinase clk2

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August undefined, 2024

WebCC-671 is a potent and selective inhibitor of both TTK (human protein kinase monopolar spindle 1 [hMps1]) and CDC like kinase 2 (CLK2). It represents a new class of cancer … http://sea.docking.org/jobs/search_dd920cdf-bc2e-44c7-9fbd-8f637cdbcca7

Cdc2-like kinases: structure, biological function, and …

WebApr 7, 2024 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12 ... WebQuery Target Key Target Name Description P-Value MaxTC; compound_1 . PARP1_RAT: Parp1: Poly [ADP-ribose] polymerase 1: 5.09e-154 gyms in reading uk

Biochemical characterization and localization of the dual specificity ...

WebDescription: Homo sapiens CDC like kinase 2 (CLK2), transcript variant 3, mRNA. (from RefSeq NM_001294339) RefSeq Summary (NM_001294338): This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of … WebPurpose: To explore the role of CDC-like kinase 2 (CLK2) in the development and progression of lung cancer and its regulatory mechanism. Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) assay was used to detect the expressions of micro ribonucleic acid (miR)-573 and CLK2 in non-small cell lung cancer … WebFeb 7, 2012 · Protein target information for Dual specificity protein kinase CLK2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. gyms in reading town centre

3NR9: Structure of human CDC2-like kinase 2 (CLK2)

Human Gene CLK2 (ENST00000368361.9) from GENCODE V43

WebDual specificity tyrosine-phosphorylation-regulated kinase 4: 6.942e-09: 0.73: CDC7_HUMAN: CDC7: Cell division cycle 7-related protein kinase: 6.953e-09: 0.32: PAR14_HUMAN: PARP14: Protein mono-ADP-ribosyltransferase PARP14: 9.916e-09: 0.30: CLK4_HUMAN: CLK4: Dual specificity protein kinase CLK4: 1.18e-08: 0.73: … WebDescription: Homo sapiens CDC like kinase 2 (CLK2), transcript variant 3, mRNA. (from RefSeq NM_001294339) RefSeq Summary (NM_001294338): This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of … bpi family savings bank passbookWebThis gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the … gyms in reading with swimming pool

"WebCalcium/calmodulin-dependent protein kinase kinase 2: 4.781e-06: 0.32: MP2K1_HUMAN: MAP2K1: Dual specificity mitogen-activated protein kinase kinase 1: 5.341e-06: 0.36: KAPCA_HUMAN: PRKACA: cAMP-dependent protein kinase catalytic subunit alpha: 6.261e-06: 0.35: AK1C1_HUMAN: AKR1C1: Aldo-keto reductase family 1 member C1: … " - Dual specificity protein kinase clk2

Dual specificity protein kinase clk2

The dual specificity protein kinase CLK3 is abundantly expressed …

WebThe cdc2-like kinases (CLKs) are an evolutionarily conserved group of dual specificity kinases belonging to the CMGC (cyclin-dependent kinases (CDKs), mitogen-activated … http://sea.docking.org/jobs/search_462fe35f-6251-418d-af8e-e6a4a6e03434

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WebApr 12, 2024 · The compound CC-671, an inhibitor of both CLK2 and the dual-specificity protein kinase TTK, blocked the growth of two cell lines and a patient-derived TNBC … WebPTHR45646:SF6 DUAL SPECIFICITY PROTEIN KINASE CLK2 1 hit; PTHR45646 SERINE/THREONINE-PROTEIN KINASE DOA-RELATED 1 hit; PROSITE. View protein in PROSITE; PS00107 PROTEIN_KINASE_ATP 1 hit; PS50011 PROTEIN_KINASE_DOM 1 hit; PS00108 PROTEIN_KINASE_ST 1 hit; Pfam. View protein in Pfam; PF00069 …

WebOct 2, 2024 · KLIFS — Kinase–Ligand Interaction Fingerprints and Structures — is a structural kinase database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. WebDescription: Homo sapiens CDC like kinase 2 (CLK2), transcript variant 2, mRNA. (from RefSeq NM_003993) RefSeq Summary (NM_003993): This gene encodes a dual …

WebJul 29, 2024 · Blog ». 29th July 2024. AI visualises every protein known to science. DeepMind's AlphaFold program has uncovered the structures of more than 200 million proteins, essentially all of those known to science. Dual specificity protein kinase CLK2, involved in regulation of several cellular processes and which may serve as a link …

WebFeb 5, 2024 · Go to Variation Viewer for CLK2 variants; Summary. This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. bpi family savings bank open on saturdayWebCLKs (Cdc2-like kinase) are dual specificity protein kinases which are involved in gene splicing regulation. The CLK family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are useful targets for studying diseases attributed to gene mis-splicing events. Products. Background. Literature (1) Gene Data. CLK (Cdc2-like Kinase) Inhibitors; gyms in redcliffeWebOct 9, 2013 · Docking studies were performed between the optimized structure of BPA and 271 proteins related to different biochemical processes, as selected by text-mining. Refinement docking experiments and conformational analyses were carried out using LigandScout 3.0 for the proteins selected through the affinity ranking (lower than … gyms in red bluff caWebCLK2_HUMAN: CLK2: Dual specificity protein kinase CLK2: 4.81e-06: 0.43: ST17A_HUMAN: STK17A: Serine/threonine-protein kinase 17A: 5.343e-06: 0.43: KPCD3_HUMAN: PRKD3: Serine/threonine-protein kinase D3: 6.63e-06: 0.43: DYRK4_HUMAN: DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase … gyms in readingWebCLK3 (gene) Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene. [5] [6] The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. gyms in raleigh nc 27616WebIn biochemistry, a dual-specificity kinase ( EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase . MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include: The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and … bpi family savings bank imusWebCDC-like kinase 2 nucleus, protein serine/threonine kinase activity, nucleotide binding, ATP binding, protein phosphorylation, protein binding, nucleolus, response to retinoic … gyms in reading with no joining fee