Cyclic pifithrin-α
WebPifithrin- α hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. WebHere, we show that in autophagy-competent mouse embryonic fibroblasts (MEFs), distinct autophagic triggers, including starvation, mTOR inhibition with rapamycin and p53 inhibition with cyclic pifithrin α lead to the activation of IKK, followed by the phosphorylation-dependent degradation of IκBα and nuclear translocation of NFκB.
Cyclic pifithrin-α
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WebMar 9, 2024 · Or cells were pre-treated with rapamycin (an activator of autophagy), 3-MA (an inhibitor of autophagy), or cyclic pifithrin-α (PFT-α, an antagonist of p53), and then treated with AOPPs. Cellular senescence was analyzed by measuring the levels of senescence-associated β-galactosidase (SA β-Gal), senescence-associated … WebPifithrin- α (PFT- α; Item No. 13326) is a reversible inhibitor of p53- dependent transcription and apoptosis. 1 Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. 2 It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC 50 = 23, 77, and 103 μM, …
WebPifithrin-α is a synthetic, water-soluble and stable inhibitor of p53 [1]. Pifithrin-α is firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. ... A4477 Cyclic Pifithrin-α hydrobromide. A4204 JNJ-26854165 (Serdemetan) A4487 WR 1065. A4203 Tenovin-1 ... WebJan 23, 2024 · In contrast, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent RCX-induced apoptosis, indicating the activation of a p53-independent apoptosis pathway. RCX also presented a...
Web以下是丝状支原体山羊亚种PCR检测试剂盒说明书的订购信息： 我司提供PCR试剂盒的类别有流感病毒、副流感病毒、呼吸道合胞病毒、冠状病毒、轮状病毒、杆菌、链球菌、热带病毒等等核酸检测试剂盒。 产品名称 丝状支原体山羊亚种PCR检测试剂盒说明书 英文名称 Mycoplasma myco WebApplication: Pifithrin-α, p-nitro, cyclic is A cell-permeable p53 inhibitor that is more potent & has a longer half-life than Pifithrin-α. CAS Number: 60477-38-5. Purity: ≥95%. Molecular Weight: 299.35. Molecular Formula: C 15 H 13 N 3 O 2 S. For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WebPifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α. - Find MSDS or SDS, a COA, data sheets and more information.
WebCyclic Pifithrin- α hydrobromide is a cyclic analog of pifithrin- α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone -induced cell death in murine … genshin training dummy locationWebMar 15, 2005 · Pifithrin-α like 2f as well as the cyclic dehydrated 6b analogue were found to be one log more potent p53 inactivators than reference compound Pft-α, with EC 50 … genshin trainer 2022WebPifithrin-α ≥95% (HPLC), powder Synonym (s): 2- (2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone hydrobromide, PFT-α Linear Formula: C16H18N2OS·HBr CAS Number: 63208-82-2 Molecular … genshin trailer 2.1WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor. genshin trailer sumeruWebCell cycle is a fundamental process underlying growth and development in evolutionarily diverse organisms, including fungi. In human fungal pathogens, cell cycle control … chris c productionsWebProduct name Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog Description Stable, cell-permeable analog of pifithrin-α. p53 inhibitor Biological description Stable, … genshin transmutation guideWeb60477-34-1. C₁₆H₁₆N₂S · HBr. Description. Overview. This product has been discontinued. A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132 ), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes ... chris crabtree golf